Recent studies elucidate pivotal molecular mechanisms in cancer. Research in Nature implicates glycosaminoglycan-driven lipoprotein uptake as a protective mechanism against ferroptosis in tumors, highlighting therapeutic targets in clear cell renal carcinoma. Separately, studies identify CCNE1’s role in hepatic precancerous lesion progression via PI3K/Akt activation and tumor-associated macrophage polarization. Additionally, a dual degrader and antagonist GDC-2992 targets androgen receptor resistance mechanisms in prostate cancer, promising to overcome therapeutic limitations.