Studies increasingly confirm that night shift work disrupts circadian rhythms, leading to a host of adverse health outcomes including cardiometabolic, autoimmune disorders, and certain cancers. Christoph Scheiermann from the University of Geneva emphasizes that misalignment of biological clocks impairs immune function and metabolism. Ongoing research aims to elucidate molecular and genetic mechanisms behind this phenomenon to inform interventions for the roughly 18-20% of workers on alternate shifts globally.