Recent research highlights the critical regulation of ribosome biogenesis during neural stem cell proliferation in brain development. Published studies reveal that post-transcriptional modifications such as N6-methyladenosine (m6A) in mRNA play a pivotal role in modulating gene expression linked to ribosome assembly. This finely tuned coordination ensures proper neurogenesis and prevents developmental anomalies. Understanding this molecular regulation offers substantial implications for developmental biology and disease states involving ribosomal dysfunction.