A comprehensive study led by the Wellcome Sanger Institute and University of Cambridge systematically examined the somatic genetic effects of chemotherapy on normal blood cells. Using whole-genome sequencing on patient samples post-treatment with various chemotherapy regimens, researchers identified distinct mutational signatures associated with specific drugs such as platinum-based agents. The findings illuminate the long-term DNA damage chemotherapy inflicts on healthy tissues, providing a foundation for developing safer treatment protocols and personalized patient management.