Recent technology breakthroughs promise enhanced diagnostic power and patient care. Researchers at King’s College London developed a nanoneedle patch with tens of millions of microscopic needles capable of painless, minimally invasive molecular tissue sampling, potentially replacing traditional biopsies for diseases like cancer and Alzheimer’s. An automated EEG tool using continuous background trend analysis was introduced to predict outcomes in newborns with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia, aiding early clinical decision-making. Brown and Morgan State Universities devised smartphone-based methodologies to quantify skin tone for improving pulse oximeter accuracy across diverse populations. Lastly, a novel microfluidic paper-based device coupled with portable mass spectrometry offers rapid, sensitive malaria detection among asymptomatic individuals in field settings.