Two major studies published in Nature detailed enhanced genomic resolution from sequencing 65 diverse human genomes, including full telomere-to-telomere assemblies and comprehensive structural variant detection. The research uncovered over 175,000 sequence-resolved structural variants affecting human genome organization. Notable findings included high diversity in centromeric regions, which were previously difficult to sequence. These insights provide a more panoramic and precise map of human genetic variation, advancing resources for disease association studies and precision medicine applications. Contributions from the 1000 Genomes Project consortium and leading research institutions were central to these efforts.