Groundbreaking research advances understanding of brain aging, neurodegeneration, and neuroimmune mechanisms. Studies revealed that altered protein synthesis impairs key neuronal proteins during aging in killifish brain models, linking translation slowdown to neurodegenerative disease markers. Epigenetic RNA modifications, such as m6A, modulate microglial phagocytosis in Alzheimer's disease models. Oligomeric alpha-synuclein structures disrupt corticostriatal signaling, underpinning early Parkinson's disease stages. Innovative video analysis detects early Parkinsonian motor dysfunction in at-risk populations. Together, these findings enhance mechanistic insights and foster avenues for novel therapeutic interventions.