Scientists at the University of Cologne introduced DynaTag, a novel technique enabling high-resolution mapping of transcription factor binding sites even in single cells and low-input samples by preserving physiological salt conditions during sample processing. Detailed in Nature Communications, this method outperforms established protocols like ChIP-seq in sensitivity and resolution. DynaTag's application to embryonic stem cells and small cell lung cancer models revealed dynamic transcription factor occupancy changes during development and chemotherapy response, offering a powerful tool for epigenomic studies and heterogeneous tissue characterization.