Recent advances target improving organ transplant outcomes and regenerative therapies. A platform for scalable production of induced mesenchymal stem cell extracellular vesicles (EVs) promises consistent quality for clinical applications. Partial heart transplantation demonstrates feasibility for complex congenital heart disease treatment with potential long-term benefits. Optimization studies in kidney and liver transplantation leverage AI and normothermic regional perfusion techniques to enhance organ viability and allocation. Complementing these, engineered ureteral tissue from pluripotent stem cells marks progress in urinary system regeneration.