Emerging molecular biomarkers and targets are reshaping oncology and hepatology. The GATOR1 complex was identified as a tumor suppressor in aggressive Myc-driven lymphoma through genome-wide CRISPR screens. Separately, chitinase-3-like protein 1 (CHI3L1) is gaining attention as a non-invasive biomarker for liver disease diagnosis and management. Further, studies revealed circ_0000847’s role in advancing colorectal cancer via IGF2BP2 binding, enriching understanding of tumor progression pathways.