Scientists isolated two novel dimeric compounds, piperasagamines A and B, from a deep‑sea Aspergillus strain (FKJ‑0404) and reported antimalarial activity in early studies. The structures represent a previously unrecognized chemical class and showed promising bioactivity against Plasmodium in laboratory assays, according to the report. The discovery underscores deep‑sea fungi as a reservoir for structurally unique natural products and provides new starting points for antimalarial lead optimization.