Haoyu Cheng at Yale unveiled hifiasm (ONT), an algorithm that assembles near end‑to‑end human genomes using standard sequencing without needing ultra‑long DNA input. The tool reduces dependency on long-read sequencing methods that require large amounts of high‑molecular‑weight DNA and are often infeasible for clinical samples. For clinical genomics and diagnostics, this lowers a major technical barrier to complete genome assembly from patient material and could accelerate adoption in research and translational settings. The method was presented in a Q&A report describing algorithmic advances and validation on human datasets.