Haoyu Cheng of Yale developed hifiasm (ONT), an algorithm that reconstructs near end‑to‑end human genomes using standard sequencing inputs, removing the need for ultra‑long DNA extractions that many clinical samples cannot support. The tool promises to lower cost and expand access to high-quality genome assemblies for research and clinical applications. Cheng’s method improves assembly contiguity and could enable more routine use of complete genome assemblies in diagnostics, rare‑disease research and population genomics. By reducing material and technical barriers, hifiasm may broaden who can perform comprehensive genomic analyses and accelerate variant discovery.