A study described neutrophils’ role in liver cancer immune evasion by identifying NET-linked gene scores that point to candidate mechanisms. The work frames cancer escape as not just T-cell exclusion but also neutrophil-derived processes. A related mechanistic thread appears in another cancer genetics update: RRM2 was identified as a gene connecting nucleotide metabolism to lipid remodeling through SREBP1/FASN pathways, contributing to gemcitabine resistance in pancreatic ductal adenocarcinoma. Together, the findings broaden the actionable map for immuno-metabolic resistance—where immune cell programs and tumor metabolism intersect to blunt therapy response.