Groundbreaking research elucidates mechanisms linking immune regulation and neurological conditions. Astrocyte-derived CXCL10 chemokine exacerbates post-intracerebral hemorrhage brain injury via CXCR3/cGAS/AIM2 pathways leading to endothelial pyroptosis and blood-brain barrier disruption. Separately, studies utilizing CRISPR and machine learning identify key genes orchestrating macrophage response to pathogens, enhancing understanding of innate immunity dynamics. These insights into cellular and molecular interactions deepen our grasp of neuroimmune interfaces critical for therapeutic targeting.