Neurodegeneration research emphasized both earlier risk mapping and mechanistic tissue drivers. Stress-tagged ubiquitin marked a soluble oligomeric tau population in Alzheimer’s brains and correlated with tau seeding activity, suggesting a potential target-linked biomarker direction. Separately, a large postmortem methylation study reported 107 brain DNA methylation sites linked to Alzheimer’s pathology and partially mediated the effect of APOE genotype on diagnosis, adding to the growing map of epigenetic intermediates. On the translational imaging side, an Alzheimer’s-adjacent computational and imaging workflow tied to mechanistic targets continues to gain traction, with blood/brain markers being explored for earlier and more specific staging.