A new Nature Reviews Neurology review argues Lewy body disease may be driven by distinct “brain-first versus body-first” pathways, helping explain why symptoms fluctuate and why neurodegeneration patterns diverge across brain scans. The framework reframes Lewy pathology variability as different origins rather than a single uniform process, setting up clearer hypotheses for stratified clinical and biomarker efforts. In another neuro disease biology thread, work linked temperature-sensing biology to how the nervous system processes warm and cool information, suggesting skin thermoreceptors can carry both types of signals via a flexible population-coding strategy rather than strict cooling/warming specialization. Finally, researchers also reported a patterned neuronal stimulation paradigm (REPOPS) in mice designed to mirror features of ECT-like activation while enabling mechanistic interrogation, aiming to clarify cellular logic behind durable neuromodulation benefits.