A post hoc analysis suggests individualized potassium-guided sodium zirconium cyclosilicate titration improves sustained predialysis potassium control in patients receiving maintenance hemodialysis. The study also reports fewer recurrent hyperkalemia events compared with less individualized approaches. For dialysis clinicians, potassium control is a persistent safety and hospitalization driver, so titration strategies that reduce recurrent hyperkalemia can influence both clinical outcomes and care utilization. The post hoc nature means the findings require confirmation in prospective studies designed for that specific titration approach. Still, the direction is clinically actionable: it supports a move toward individualized dosing protocols that track patient-specific potassium kinetics rather than fixed regimens.