The National Center for Advancing Translational Sciences (NCATS) at NIH announced the OligoTox Open Data Challenge, a two‑phase competition offering up to $500,000 to generate high‑quality, open datasets on oligonucleotide toxicity from in vitro human systems. The program seeks datasets to train predictive in silico models relating sequence and chemical modifications to toxicity, with phase one focused on ideation and phase two on dataset generation and public contribution. Eligibility and timelines were published alongside challenge rules.