A Nature study released population‑scale analyses of somatic mutations and selection across human tissues using ultra‑deep duplex sequencing. The authors combined very high‑coverage sequencing with statistical frameworks to identify mutation hotspots and evidence of positive selection operating in renewing tissues. The work catalogues drivers of clonal expansions and highlights how somatic selection shapes mutational landscapes relevant to cancer and age‑related disease. The paper also establishes methods for detecting rare variant accumulation and offers datasets that will inform both basic biology and clinical risk prediction.