The NIH has announced a $50 million research program aiming to elucidate genetic and environmental factors driving autism spectrum disorder. The Autism Data Science Initiative funds 13 projects using large-scale genomic, epigenomic, metabolomic, proteomic, clinical, and behavioral datasets to improve diagnosis and treatment. Leading institutions including Boston Children’s Hospital, UCLA, and the Children’s Hospital of Philadelphia will collaborate with autism communities to align research priorities. This initiative reflects a growing effort to integrate multi-omic data for comprehensive understanding of complex neurodevelopmental disorders.