Dana-Farber researchers developed Hifiasm (ONT), an algorithm capable of assembling near telomere-to-telomere human genomes using standard nanopore sequencing reads without requiring ultra-long reads. Utilizing enhanced error correction adapted for nanopore data, the tool achieves highly complete genome assemblies, lowering sequencing data requirements and simplifying workflows. This advance expands accessibility to fully assembled human genomes for biomedical research.