Swiss biotech 4bases and researchers from the University of Florence launched clinical pilot studies in two Italian hospitals to validate nanopore sequencing–based cytogenetics for real‑time detection of copy‑number variants. The KaryoSolver workflow—comprising KaryoPrep library prep and KaryoSolver software—uses PromethIon throughput to shorten turnaround to roughly 24 hours and increase sample multiplexing. Investigators plan to compare KaryoSolver against array‑CGH in real‑world patient samples. If pilots confirm speed and concordance, 4bases expects to commercialize the workflow in Q2, offering clinical labs a faster option for CNV detection and potentially disrupting standard cytogenetic pipelines.