Researchers adapted nanopore sequencing to analyze plasma cell‑free DNA from critically ill patients, demonstrating simultaneous tissue‑of‑origin signals and pathogen detection in a single stream from cfDNA. The study, published by a translational medicine team, shows that long‑read nanopore approaches can resolve fragmentomic signatures and microbial genomes in real time, offering a minimally invasive method for diagnosing sepsis and tissue injury. Authors noted the method’s potential to shorten time to actionable results in ICU settings, though larger validation and integration with clinical workflows are needed.