Researchers demonstrated that nanopore sequencing of plasma cell‑free DNA can simultaneously capture tissue‑of‑origin signals and identify pathogenic sequences in critically ill patients. The approach leverages long‑read sequencing to resolve fragmentomic and microbial features from a single sample, potentially enabling faster, minimally invasive diagnostics in intensive care settings. Study authors highlighted the method’s real‑time capabilities and suggested clinical utility for sepsis and multi‑organ injury, while noting the need for larger validation studies and standardized interpretation pipelines.