Researchers at King's College London have created a nanoneedle patch equipped with millions of microscopic silicon needles thousands of times thinner than human hair, designed to collect molecular information directly from living tissues without causing damage or pain. This technology allows real-time, repeated molecular monitoring of diseases like cancer and Alzheimer’s, overcoming limitations of traditional biopsies. The patch’s minimally invasive approach promises to transform diagnostics by enabling detailed spatial lipidomics over time, enhancing study of tissue dynamics and therapeutic response.