Multiomics and single-cell genomics techniques are transforming biological research and precision medicine. Experts at GEN’s virtual summit detailed how spatial proteomics is enhancing understanding of disease progression and therapeutic response, particularly in oncology. Furthermore, scaling single-cell RNA sequencing is enabling detailed cell mapping, revealing cellular heterogeneity and interaction in various diseases, including cancer and immunology. Collectively, these advances provide granular molecular insights critical for future diagnostics and treatments.