A multi‑omics spatial study in pediatric acute respiratory distress syndrome (ARDS) identified discrete lung compartments associated with tissue repair, providing a molecular atlas of cellular states during recovery. Published in the Journal of Translational Medicine, the work integrates spatial transcriptomics and proteomics to localize repair‑associated cell populations and signaling axes. Multi‑omics combines genomic, transcriptomic and proteomic data to reveal coordinated molecular programs; here it isolates candidate repair niches that could be targeted to accelerate regeneration in pediatric ARDS. The dataset offers translational groups potential biomarker signatures and cellular targets for interventional studies in pediatric critical care.