Researchers published in Nature Microbiology that an mRNA vaccination approach overcame haemozoin‑mediated immune suppression and restored efficacy of whole‑parasite malaria vaccines in mice. The study mapped how haemozoin, a Plasmodium digestion by‑product, impairs immune responses and showed the mRNA formulation reversed that effect, enabling protective immunity in murine models. Authors recommend the strategy for improving whole‑parasite vaccine candidates facing haemozoin‑linked dampening of host responses; the results provide a preclinical pathway for pipeline teams tackling malaria vaccine barriers.