Nature Biotechnology published work showing that antimicrobial peptides delivered as mRNA‑encoded peptibodies in lipid formulations eradicated multidrug‑resistant bacterial pneumonia in mouse models. The approach combined optimized mRNA constructs with anti‑inflammatory lipid carriers to both kill pathogens and temper host damage. Authors reported robust bacterial clearance, reduced inflammatory markers and improved survival versus controls, positioning mRNA‑encoded biologics as a flexible platform for infectious disease where traditional antibiotics fail. The study points to intrapulmonary delivery as a route to maximize local concentrations while limiting systemic toxicity. Translational hurdles remain — including scalable inhaled/lung delivery systems, immunogenicity of repeat dosing and regulatory pathways for nucleic‑acid based antimicrobials — but the data advance a novel modality for tackling respiratory MDR infections.