Two molecular studies report findings with translational implications. Researchers showed Adipose Triglyceride Lipase (ATGL) can sensitize hepatocellular carcinoma cells to chemotherapy through p53‑mediated pathways, suggesting metabolic modulation as a strategy to improve drug response in liver cancer models. Complementing that, a HKUST team resolved how human DICER cleaves microRNAs with single‑nucleotide precision, clarifying a core step in RNA interference and miRNA biogenesis. The structural and mechanistic details could inform RNA‑based therapeutic designs and refine approaches that harness or inhibit miRNA processing in disease.