Targeting mitochondrial dysfunction presents a promising strategy for neurodegenerative diseases such as Alzheimer's and frontotemporal dementia. Researchers developed mitoDREADD-Gs, a mitochondria-specific receptor that enhances energy production by activating G-protein signaling within mitochondria. Activation of this receptor restored cognitive function in mouse models of neurodegeneration, establishing a causal link between mitochondrial impairment and disease symptoms. This molecular tool may pave the way for novel therapies focused on mitochondrial health to combat neurodegenerative disorders.