Emerging research elucidates the pivotal role of mitochondrial dynamics—specifically fission, fusion, and turnover—in aggressive breast cancers such as triple-negative subtypes. Disrupted balance favoring excessive mitochondrial fission enhances tumor proliferation, metastatic potential, and cancer stem-like properties by supporting metabolic adaptability. Key enzymes involved in lipid metabolism and oxidative phosphorylation pathways cooperate to drive tumor growth. These mechanistic insights identify mitochondrial regulation as a promising therapeutic avenue to counteract treatment-resistant breast cancers.