Emerging research reveals the gut-immune-brain axis's pivotal role in neurodegenerative disorders such as Alzheimer’s disease, with immune cells migrating from the gut to brain regions associated with inflammation. High-fiber diets demonstrate potential in mitigating such neurological pathologies. Additionally, studies link gut microbiome transplantation and metabolic health impacts in obesity, further emphasizing microbiota's influence on systemic disease. These findings open avenues for novel dietary and microbial interventions in complex chronic conditions.