A multi-drug resistance genomic analysis of poultry meat in Accra found contamination in 71 out of 246 samples, including strains carrying outbreak-associated ST19 lineages and high rates of multidrug resistance. The work uses whole-genome sequencing to characterize resistant profiles in food-chain isolates. The study strengthens the case for integrating genomic surveillance into antimicrobial stewardship efforts by connecting food sourcing to specific resistance patterns and outbreak-linked clones. For public health and biotech-adjacent stakeholders, the results add to the evidence base that resistance surveillance needs to span beyond clinical settings into production and distribution environments.