Researchers at the Centre for Cellular and Molecular Biology (CCMB) reported that metabolic pathways underlie fungal invasion and influence responses to antifungal therapy. The team identified metabolic nodes that enable pathogenic fungi to invade tissues and resist treatment, suggesting new targets for antifungal drugs. Given rising hospitalizations and limits of current antifungals, the findings provide a mechanistic basis for next‑generation therapies that focus on pathogen metabolism rather than traditional cell‑wall or membrane targets. Translational work will need to validate targets in clinical isolates and evaluate safety of metabolic inhibitors in mammalian hosts.