Recent studies have revealed the critical role of metabolic dynamics within the melanoma tumor microenvironment in mediating immune evasion and limiting immunotherapy effectiveness. Alterations in tumor cell metabolism affect immune cell function and checkpoint blockade responses, presenting new therapeutic opportunities. Targeting metabolic pathways alongside immunotherapies may enhance anti-tumor efficacy. Understanding these interactions is key to overcoming resistance in melanoma, the research highlights, underscoring the importance of integrating metabolic reprogramming strategies into treatment paradigms.