Research unveiled intricate metabolic and immunological pathways influencing disease states. A novel metabolite transporter interaction optimizes cellular glucose uptake and energy fluxes, redefining metabolic regulation. Cancer-associated fibroblasts orchestrate extracellular matrix dynamics promoting therapy resistance. New evidence revealed that circulating gut γδ T17 cells drive brain inflammation via the STING pathway in sepsis-associated encephalopathy. MARCO receptor was identified as vital for myeloid-derived suppressor cell differentiation and immunosuppression. Understanding these mechanisms provides promising targets for immunometabolic therapies across oncology and neuroinflammatory disorders.