Insights from recent research elucidate complex metabolic and immune mechanisms influencing cancer progression and obesity-related immunity. Studies published in Nature Metabolism reveal that the fat cell metabolite N-acetylaspartate controls postprandial body temperature. Another study identifies how dietary fat source modulates anti-tumor immunity in obese mice. Furthermore, research demonstrates that cancer cells induce protumor macrophages via oxidized LDL-mediated metabolic interplay in hepatocellular carcinoma, underlining metabolic-immune crosstalk as a crucial element in cancer biology.