A University of Copenhagen team presented single‑particle analyses showing that disordered lipid nanoparticles (LNPs) release RNA cargo inside cells more effectively than highly organized particles. The group, led by postdoc Artu Breuer, used a high‑throughput method to measure millions of particles and identified two subpopulations: organized particles that tightly sequester cargo and amorphous particles that release payloads more readily. The data, presented at the Biophysical Society Annual Meeting, challenge the prevailing formulation goal of maximizing cargo packing density. Researchers argue that overly organized LNPs hold RNA too tightly, limiting cytosolic release and intracellular activity — a one‑sentence clarification: LNPs are lipid‑based carriers that encapsulate RNA and rely on cellular uptake and endosomal escape to deliver therapeutic nucleic acids. If reproducible, the finding will influence LNP design for vaccines and therapeutics and could prompt reformulation efforts across companies using LNP platforms.