The University of Texas MD Anderson Cancer Center launched a $2.5 billion philanthropic campaign, 'Only Possible Here — The Campaign to End Cancer,' aimed at accelerating cancer research, expanding clinical capabilities, and supporting patient care infrastructure. The initiative represents MD Anderson’s largest fundraising effort to date. The campaign targets investments in basic and translational research, clinical trial capacity, and programs designed to speed the translation of discoveries into patient therapies. MD Anderson framed the drive as a strategic effort to sustain leadership amid funding competition and rising research costs. If fully realized, the campaign could reshape institutional priorities, enable larger translational collaborations, and support equipment and talent recruitment needed for next‑generation oncology research.