Scientists introduced MAP‑X, a technique that charts protein complex dynamics across Plasmodium falciparum’s intraerythrocytic developmental cycle, revealing stage‑specific interactions that drive parasite biology. The method uncovers temporal protein assemblies and offers a roadmap to prioritize drug targets that are essential at defined lifecycle points. Malaria drug discovery benefits from tools that reveal transient protein complexes and reveal vulnerabilities not apparent in static assays. MAP‑X could guide selection of targets less prone to resistance and inform timing of drug delivery to coincide with vulnerable parasite stages.