A novel genetic strategy using CRISPR-Cas9 to edit a single amino acid in the mosquito FREP1 gene confers resistance to malaria parasite transmission. Rather than eliminating mosquitoes or introducing foreign genes, this 'allelic-drive' technique reshapes mosquito populations by favoring a naturally occurring variant that disables parasite spread without harming mosquito viability. Developed collaboratively by teams at UC San Diego and Johns Hopkins, this approach offers a promising third path in malaria control to complement population suppression and antibody-mediated blocking.