Scientists have engineered a CRISPR-Cas9 gene editing system that modifies a single amino acid in the mosquito FREP1 gene, rendering mosquitoes unable to transmit malaria parasites. Unlike previous gene drives aiming to suppress mosquito populations, this allelic-drive strategy reshapes mosquito populations to favor malaria-resistant variants without introducing foreign genes. The drive efficiently propagates the protective allele through wild populations, offering a promising new genetic approach to combat malaria transmission and reduce disease burden.