Researchers at ETH Zurich described a clinically oriented magnetically guided microrobotic system that navigates complex vasculature to place and dissolve drug‑loaded capsules at target sites, reporting in Science. The platform integrates electromagnetic navigation, imaging, and a dissolvable payload to deliver therapeutics in large‑animal models including sheep and pigs. In vivo tests demonstrated controlled guidance through small vessels, localized heating to dissolve microrobots, and focal drug release with minimal off‑target exposure. Authors argue the approach could reduce systemic dosing and limit adverse events in conditions like stroke and localized thrombus. Translational steps include scaling device control, ensuring biocompatibility of materials, and defining regulatory pathways for implantable or transient microrobotic therapeutics.
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