Scientists at Howard Hughes Medical Institute uncovered a mechanism explaining how longevity traits are inherited across generations in C. elegans. Lysosomal metabolic changes in parent worms induce epigenetic modifications through histone transport to reproductive cells, enabling transgenerational transmission of lifespan extension without altering DNA sequence. Published in Science, this discovery provides novel insights into epigenetic inheritance mediated by intracellular organelles, broadening understanding of aging biology.