Recent studies explore lifelong respiratory consequences of very low birth weight (VLBW) and antenatal inflammation. One investigation published in Pediatric Research follows adults born with VLBW, documenting trajectories of lung function decline from young to mid-adulthood, while another links prenatal inflammation to late pulmonary hypertension via vascular remodeling in bronchopulmonary dysplasia models. These findings elucidate developmental origins of chronic respiratory diseases and underscore early-life exposures as critical determinants for adult pulmonary health.