Two international research groups employed Oxford Nanopore long-read sequencing to analyze more than 1,000 genomes from the 1000 Genomes Project, detecting novel structural variants (SVs) including insertions, deletions, and inversions. They identified roughly 15,000 to 21,000 SVs per individual, uncovering many previously undocumented variants. This expanded SV catalog improves the resolution for studying genetic variation linked to disease, underscoring the power of long-read technologies in genomics and precision medicine.