Researchers have developed innovative light-activated pills that enable noninvasive exploration of the gut's complex nervous system, often referred to as the body's 'second brain.' This technology circumvents the limitations of traditional invasive methods that disrupt normal gut function. By controlling neural activity within the gastrointestinal tract with light-sensitive compounds delivered orally, the approach offers unprecedented opportunities to elucidate gut-brain interactions, with potential implications for treating gastrointestinal and neurological disorders.