The U.S. Department of Health and Human Services (HHS) and the Centers for Disease Control and Prevention (CDC) face significant internal turmoil under Secretary Robert F. Kennedy Jr.’s leadership. Recent events include the controversial firing of the CDC’s director, Susan Monarez, and resignations of senior scientists amid disagreements over vaccine policies, particularly regarding Covid-19 and childhood immunizations. Senate hearings saw bipartisan criticism, calls for Kennedy’s resignation, and concerns about undermined scientific credibility within public health agencies. This upheaval has prompted state-level actions, such as Pacific Coast states forming a health alliance to preserve vaccine recommendations against shifting federal policies.